Is it safe to ship a duffel bag?

Can you answer Mary Kate’s question about Luggage?:

Well im going to camp up in North Carolina in about two weeks. I am flying up there and the camp says to ship your luggage a week ahead. I am shipping a large trunk and a VERY large duffel bag with all my clothing and other stuff in it (UPS). Is it okay to ship a duffel bag? What i am saying is, will the zippers of the bag come undone in the process or be tampered with? Is there a chance of losing anything?

Samsonite Hardside Luggage